sildenafil 20 mg for erectile dysfunction

Sildenafil oral tablet is used to treat erectile dysfunction (ED). Avoid or Use Alternate Drug. Stop taking sildenafil and get medical help right away if these effects occur.In the rare event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and get medical help right away, or permanent problems could occur.A very serious allergic reaction to this drug is rare. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. chloramphenicol will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Not recommended during and 2 weeks after itraconazole treatment when sildenafil is used for pulmonary arterial hypertension. ivosidenib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated (1)cobicistat will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: additive vasodilation. Risk of hypotension. In combination with sexual stimulation, sildenafil works by increasing blood flow to the. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Use Caution/Monitor. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Men who used tadalafil were able to achieve erections 24 hours after administration, improving overall satisfaction related to the possible spontaneity of sexual encounters. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor Closely (1)nebivolol increases effects of sildenafil by additive vasodilation. Contraindicated. Use Caution/Monitor. Serious - Use Alternative (1)tucatinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. coq10 for erectile dysfunction and cialis daily vs 36 hour? nirmatrelvir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. The generic strengths of Revatio and Viagra are not interchangeable. When used for erectile dysfunction, consider reducing initial sildenafil dose of 25 mg in patients also taking a strong CYP3A4 inhibitor and monitor for sildenafil toxicities (eg, dyspepsia, headache, hypotension). Use Caution/Monitor. Increased systemic exposure of these drugs may occur with clarithromycin; consider reduction of dosage for phosphodiesterase inhibitors. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Share cases and questions with Physicians on Medscape consult. Use Caution/Monitor. Severe (eg, cirrhosis): Consider initial dose of 25 mg, Mild or moderate (Child-Pugh A or B): No dose adjustment required, Mild or moderate (CrCl 30-80 mL/min): No dose adjustment required, Severe (CrCl <30 mL/min): Consider initial dose of 25 mg, Any severity, including severe (CrCl <30 mL/min): No dose adjustment required, Maximum dose in pediatric patients not identified, Based on experience in adults, dose may be titrated up to 40 mg TID, if required, based on symptoms and tolerability, elvitegravir/cobicistat/emtricitabine/tenofovir DF, ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC), Body as a whole: Face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury, Cardiovascular: Angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy, Digestive: Vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis, Hemic and lymphatic: Anemia and leukopenia, Metabolic and nutritional: Thirst, edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia, Musculoskeletal: Arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis, Nervous: Ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia, Respiratory: Asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, sputum increased, cough increased, Skin and appendages: Urticaria, herpes simplex, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis, Special senses: Sudden decrease or loss of hearing, mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes, Urogenital: Cystitis, nocturia, urinary frequency, breast enlargement, urinary incontinence, abnormal ejaculation, genital edema and anorgasmia, Coadministration with nitrates (either regularly and/or intermittently) and nitric oxide donors, Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates, A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined, Potential for cardiac risk with sexual activity in patients with preexisting cardiovascular disease; therefore, treatment for erectile dysfunction generally should not be instituted in men for whom sexual activity is inadvisable because of their underlying cardiovascular status, Evaluate underlying causes of erectile dysfunction or BPH before initiating therapy, In small, prematurely terminated study of patients with PAH secondary to sickle-cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported by patients who received sildenafil than by those randomized to placebo; effectiveness of sildenafil in PAH secondary to sickle-cell anemia has not been established; the clinical relevance to men treated for erectile dysfunction with sildenafil is not known, Epistaxis occurred in 13% of patients with PAH secondary to connective tissue disease (eg, scleroderma); this effect was not seen in idiopathic PAH; incidence was also higher in those receiving concomitant PO vitamin K antagonist therapy (9%) than in those not receiving such therapy (2%), CYP3A substrate (major route); CYP2C9 substrate (minor route), Consistent with its known effects on the nitric oxide/cGMP pathway, sildenafil was shown to potentiate the hypotensive effects of nitrates, Viagra: Modify dose; not to exceed single dose of 25 mg/48 hr, Coadministration increases systemic exposure of sildenafil and risk of adverse effects, Revatio: Modify dose; upward dose titration may be needed if coadministered, Coadministration with moderate-to-strong CYP3A inducers (eg, bosentan) decreases the sildenafil exposure and possibly reduces efficacy, Additive adverse effects may occur if coadministered with other PDE5 inhibitors (eg, avanafil, tadalafil, vardenafil), Coadministration may increase risk of hypotension, Particularly with higher doses used for erectile dysfunction, Take as needed, about 1 hr before sexual activity; however, may be taken anywhere from 30 minutes to 4 hr before sexual activity, The maximum recommended dosing frequency is once daily, Reconstitute bottle contents with water (total volume of 90 mL [60 mL followed by 30 mL]), Refer to prescribing information for detailed instructions, Do not mix with any other medication or additional flavoring agent, Store at controlled room temperature 20-25C (68-77F), Excursions permitted to 15-30C (59-86F), Store <30C (86F) or in a refrigerator between 2-8C (36-46F), Discard unused oral suspension after 60 days. The 20 mg strength of sildenafil generic is the same as Revatio. Do not store in the bathroom. Sildenafil does not protect you from STIs. . Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor Closely (1)aprepitant will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you log out, you will be required to enter your username and password the next time you visit. ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. . Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. diltiazem will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Benefits of Taking Viagra Daily - Healthline Contraindicated (1)sildenafil increases effects of nitroglycerin rectal by additive vasodilation. Enhanced hypotensive effects. 5 or 20 mg orally three times a day, 4 to 6 hours apart-Maximum dose: 20 mg orally three times a day Contraindicated. dexamethasone will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)labetalol increases effects of sildenafil by additive vasodilation. Serious - Use Alternative (1)crizotinib increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CMP Pharma, Inc Announces that Liqrev, the First and Only Ready-made Avoid or Use Alternate Drug. When used chronically for PAH, sildenafil is contraindicated for use with cobicistat; if used for erectile dysfunction, do not exceed sildenafil 25 mg q48hr. Avoid or Use Alternate Drug. anti-hypertensive channel blocking. Increased systemic exposure of these drugs may occur with clarithromycin; consider reduction of dosage for phosphodiesterase inhibitors. Consider a starting dose of 25 mg in patients treated with erythromycin. Use Caution/Monitor. When used for erectile dysfunction, consider reducing initial sildenafil dose of 25 mg in patients also taking a strong CYP3A4 inhibitor and monitor for sildenafil toxicities (eg, dyspepsia, headache, hypotension). If you already use medicine for high blood pressure (hypertension), sildenafil could make your blood pressure go too low. Quick Links. Minor/Significance Unknown. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor Closely (1)acebutolol increases effects of sildenafil by additive vasodilation. Different brands may not work the same way. Possible additive vasorelaxation, leading to low blood pressure. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. The drug comes in low-dose versions that can be taken daily. Sildenafil: Usage, Dosage & Side Effects - Drugs.com Minor/Significance Unknown. cyclosporine will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consult your pharmacist or local waste disposal company. This drug is available at a middle level co-pay. Sildenafil is a prescription drug. acetazolamide will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)duvelisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. Serious - Use Alternative (1)lonafarnib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use of Sildenafil (Viagra) in Patients With Cardiovascular Disease Use Caution/Monitor. Serious - Use Alternative (1)voxelotor will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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